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The prevalence of diabetes is increasing throughout Asia, even in the absence of obesity, and is lower in women than in men. The underlying mechanisms are not well understood. To evaluate the sex differences in glucose and fatty acid metabolism in Asians who are nonobese. Insulin sensitivity insulin-mediated glucose uptake normalized for steady-state insulin; hyperinsulinemic-euglycemic clamp , postprandial glucose, insulin and fatty acid concentrations, insulin secretion mixed meal tolerance test with mathematical modeling , insulin clearance, body composition and fat distribution dual-energy X-ray absorptiometry, MRI, and spectroscopy , cardiorespiratory fitness maximal oxygen uptake; graded exercise test , and handgrip strength dynamometry.

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